The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
Tolerance and efficacy of Amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in haematological patients.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1997 May;16;364-8 — 1997 May — 364-8
The physiologic effects of inhaled amphotericin B.
Chest 1995 Sep;108;750-3 — 1995 Sep — 750-3
Rapid infusion amphotericin B: effective and well-tolerated therapy for neutropenic fever.
Pharmatherapeutica 1989;5;305-11 — 1989 — 305-11