The Drug-Induced Respiratory Disease Website

BCG therapy (topical instillations in the urinary bladder)

Acute lung injury - ARDS

Reported in an Infant with severe combined immunodeficiency

Sohail S, Afzal M, Anwar V, Shama Q

Disseminated Bacille Calmette-Guerin (BCG) disease in an infant with severe combined immunodeficiency.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2014 Nov;24 Suppl 3;S259-61 — 2014 Nov — S259-61

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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