The Drug-Induced Respiratory Disease Website

Caffeine

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Arrhythmias-Dysrhythmias, including atrial fibrillation (Review at PMID 15582307), ventricular tachycardia/fibrillation See also under torsades de pointe under XIIt

Publications

Aknouche F, Guibert E, Tessier A, Eibel A, Kintz P

Suicide by ingestion of caffeine.

Egyptian journal of forensic sciences 2017;7;6 — 2017 — 6

Ciszowski K, Biedro? W, Gomólka E

Acute caffeine poisoning resulting in atrial fibrillation after guarana extract overdose.

Przeglad lekarski 2014;71;495-8 — 2014 — 495-8

Bioh G, Gallagher MM, Prasad U

Survival of a highly toxic dose of caffeine.

BMJ case reports 2013 Feb 08;2013; — 2013 Feb 08

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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