The Drug-Induced Respiratory Disease Website

Respiratory distress or failure, not otherwise specified

Publications

Day R, Bradberry SM, Thomas SHL, Vale JA

Liquid laundry detergent capsules (PODS): a review of their composition and mechanisms of toxicity, and of the circumstances, routes, features, and management of exposure.

Clinical toxicology (Philadelphia, Pa.) 2019 Nov;57;1053-1063 — 2019 Nov — 1053-1063

Stromberg PE, Burt MH, Rose SR, Cumpston KL, Emswiler MP, Wills BK

Airway compromise in children exposed to single-use laundry detergent pods: a poison center observational case series.

The American journal of emergency medicine 2015 Mar;33;349-51 — 2015 Mar — 349-51

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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