The Drug-Induced Respiratory Disease Website

Cocaine

Systemic arterial thrombosis

Paulin Vera CM, Mateos Colin A, Calvo Arrojo G, Colodro García JM

Acute aortoiliac thrombosis due to cocaine intake.

Annals of vascular surgery 2013 Feb;27;239.e1-4 — 2013 Feb — 239.e1-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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