The Drug-Induced Respiratory Disease Website

Anthracyclines

Late left ventricular dysfunction/failure

May develop insidiously after years into treatment or after termination of treatment with the culpable drug

Lipshultz SE

Exposure to anthracyclines during childhood causes cardiac injury.

Seminars in oncology 2006 Jun;33;S8-14 — 2006 Jun — S8-14

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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