The Drug-Induced Respiratory Disease Website

Methadone

Respiratory arrest - Apnea

See also under IXd, IXa, IXd, IXs, XIIm. Review of causal agents on PMID 30553870

Lusetti M, Licata M, Silingardi E, Reggiani Bonetti L, Palmiere C

Therapeutic and recreational methadone cardiotoxicity.

Journal of forensic and legal medicine 2016 Apr;39;80-4 — 2016 Apr — 80-4

Swenson O

Accidental methadone intoxication masquerading as asthma exacerbation with respiratory arrest in a six-year-old boy.

Delaware medical journal 2015 May;87;147-9 — 2015 May — 147-9

Aghabiklooei A, Hassanian-Moghaddam H, Zamani N, Shadnia S, Mashayekhian M, Rahimi M, Nasouhi S, Ghoochani A

Effectiveness of naltrexone in the prevention of delayed respiratory arrest in opioid-naive methadone-intoxicated patients.

BioMed research international 2013;2013;903172 — 2013 — 903172

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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