The Drug-Induced Respiratory Disease Website
Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
Evidence level
low
Lone, isolated, free-flowing pleural effusion on imaging. See other forms of pleural effusions under Vb, d, e, g, h, i, m which may present similarly on imaging. The effusion can be uni- or bilateral. More often a lymphocyte-, mixed or neutrophil-rich exudate. At times the effusion is eosipophil-rich. Pleural effusion can be present with the acute clinical phase of severe drug-induced ILD (e.g. methotrexate lung; PMID 16840219). In general, pleural effusion in the context of drug-induced ILD or pulmonary edema is not tabulated under this heading. ANA-panel indicated to diagnose drug-induced lupus PMID 10424528
Publications
Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC.
Case reports in oncology 2021 Sep-Dec;14;1323-1327 — 2021 Sep-Dec — 1323-1327
Gadgeel SM, Gandhi L, Riely GJ, Chiappori AA, West HL, Azada MC, Morcos PN, Lee RM, Garcia L, Yu L, Boisserie F, Di Laurenzio L, Golding S, Sato J, Yokoyama S, Tanaka T, Ou SH
Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study.
The Lancet. Oncology 2014 Sep;15;1119-28 — 2014 Sep — 1119-28