The Drug-Induced Respiratory Disease Website

Carfilzomib

Alveolar hemorrhage (AH), diffuse AH (DAH)

Causality assessment in myeloma patients with low platelet counts is problematic (e.g. PMID 25944347)

Kwong YL

Fatal pulmonary hemorrhage after carfilzomib treatment in multiple myeloma.

Annals of hematology 2015 Aug;94;1425-6 — 2015 Aug — 1425-6

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.