The Drug-Induced Respiratory Disease Website

Thrombolytic (fibrinolytic) agents

Hemopericardium - Bloody pericardial effusion

Large effusions can cause cardiac tamponade. May occur late into treatment with anticoagulants

Mohammad S, Austin SM

Hemopericardium with cardiac tamponade after intravenous thrombolysis for acute myocardial infarction.

Clinical cardiology 1996 May;19;432-4 — 1996 May — 432-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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