The Drug-Induced Respiratory Disease Website

Angiotensin converting enzyme inhibitors (ACEI)

Visceral angioedema

Can manifest acutely with abdominal pain

Squillante MD, Trujillo A, Norton J, Bansal S, Dragoo D

ACE Inhibitor Induced Isolated Angioedema of the Small Bowel: A Rare Complication of a Common Medication.

Case reports in emergency medicine 2021;2021;8853755 — 2021 — 8853755

Thalanayar PM, Ghobrial I, Lubin F, Karnik R, Bhasin R

Drug-induced visceral angioedema.

Journal of community hospital internal medicine perspectives 2014;4; — 2014

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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