The Drug-Induced Respiratory Disease Website

Ticagrelor

Angioedema (may cause UAO, asphyxia and death)

May be a further increase in ACEI/ARB angioedema incidence (PMID 23023302)

Seecheran R, Seecheran V, Persad S, Lalla S, Seecheran NA

Ticagrelor-Induced Angioedema: A Rare and Unexpected Phenomenon.

Case reports in cardiology 2017;2017;7612713 — 2017 — 7612713

DiNicolantonio JJ, Serebruany VL

Angiotensin receptor blockers worsen renal function and dyspnea on ticagrelor: a potential ticagrelor-angiotensin receptor blocker interaction?

Clinical cardiology 2012 Nov;35;647-8 — 2012 Nov — 647-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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