The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
Life-threatening bronchospasm induced by an angiotensin-converting enzyme inhibitor in a chronically ventilated patient: Diagnostic pitfalls and literature review.
Respirology case reports 2023 Oct;11;e01224 — 2023 Oct — e01224
The presence of underlying asthma should be investigated in patients diagnosed with ACE inhibitor induced cough.
The clinical respiratory journal 2020 Jan 04;; — 2020 Jan 04
ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.
Drug safety 1996 Jul;15;72-8 — 1996 Jul — 72-8
Angiotensin converting enzyme inhibitors and asthma.
BMJ (Clinical research ed.) 1994 Feb 26;308;593-4 — 1994 Feb 26 — 593-4
Captopril-related (and -induced?) asthma.
The American review of respiratory disease 1987 Oct;136;999-1000 — 1987 Oct — 999-1000