The Drug-Induced Respiratory Disease Website

Silicone, fluid

Silicone pneumonitis - 'Silicone lung'

May lad to diffuse alveolar hemorrhage and/or ARDS. See also under VIm

Lyapichev K, Chinea FM, Poveda J, Pereda J, Bejarano PA, Garcia-Buitrago MT

Pulmonary Empty Spaces: Silicone Embolism-A Decade of Increased Incidence and Its Histological Diagnosis.

Case reports in pathology 2016;2016;3741291 — 2016 — 3741291

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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