The Drug-Induced Respiratory Disease Website

Nitrofurantoin

Respiratory arrest - Apnea

See also under IXd, IXa, IXd, IXs, XIIm. Review of causal agents on PMID 30553870

Çoban H

Respiratory arrest due to nitrofurantoin treatment in the absence of pulmonary pathology.

Journal of basic and clinical pharmacy 2015 Sep;6;115-6 — 2015 Sep — 115-6

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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