The Drug-Induced Respiratory Disease Website

Benzodiazepines

Respiratory acidosis - Hypercapnia - Elevated blood CO2

See also under neuromuscular involvement.

Alonso T, García E, Segrelles G, Zamora E

Respiratory acidosis secondary to drug therapy.

Archivos de bronconeumologia 2015 Apr;51;204-5 — 2015 Apr — 204-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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