The Drug-Induced Respiratory Disease Website

Amphotericin B (infusion)

Fluid retention

May manifest with weight gain, tissue edema, cardiomegaly and electrlyte disturbances. See also under Xc

Chung DK, Koenig MG

Reversible cardiac enlargement during treatment with amphotericin B and hydrocortisone. Report of three cases.

The American review of respiratory disease 1971 Jun;103;831-41 — 1971 Jun — 831-41

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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