The Drug-Induced Respiratory Disease Website
(Fr: toux chronique isolée). Can be transient or longlasting. Lone: withouth explanatory pulmonary infiltrates, pulmonary edema (sometimes interstitial and subclinical), bronchospasm, pleural effusion, lympnode enlargement, or airway inflammation and/or endobronchial changes. Typically the cough is subacute or chronic, dry and/or nagging. New, lone otherwise unexplained, sometimes intractable cough. For cough workup see PMID 24079681. Typically, drug-induced lone cough is subacute or chronic, dry, nonproductive, annoying and not amenable to inhaled bronchodilator, corticosteroid or other therapies. Only drug discontinuation will be effective. May cause urinary incontinence, hernia or cough syncope. A cause for cough other than and unveiled by the drug (e.g. asthma, lung cancer) should be looked for carefully. With most drugs quoted under the present pattern, cough was lone. Cough may be the annunciating or presenting feature of drug-induced ILD, particularly during methotrexate or amiodarone pulmonary toxicity (PMID: 23097577) Patients may experience the cough syncope
Publications
Falsely Accused? Insufficient Evidence to Conclude that Sitagliptin is a Cause of Chronic Cough.
Lung 2020 Jan 24;; — 2020 Jan 24
The presence of underlying asthma should be investigated in patients diagnosed with ACE inhibitor induced cough.
The clinical respiratory journal 2020 Jan 04;; — 2020 Jan 04
Chronic Cough.
The New England journal of medicine 2016 Oct 20;375;1544-1551 — 2016 Oct 20 — 1544-1551
Brugts JJ, Arima H, Remme W, Bertrand M, Ferrari R, Fox K, DiNicolantonio J, MacMahon S, Chalmers J, Zijlstra F, Caliskan K, Simoons ML, Mourad JJ, Boersma E, Akkerhuis KM
The incidence and clinical predictors of ACE-inhibitor induced dry cough by perindopril in 27,492 patients with vascular disease.
International journal of cardiology 2014 Oct 20;176;718-23 — 2014 Oct 20 — 718-23
Thoughts on one thousand chronic cough patients.
Lung 2012 Dec;190;593-6 — 2012 Dec — 593-6
Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
PloS one 2012;7;e37396 — 2012 — e37396
Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines.
Chest 2006 Jan;129;169S-173S — 2006 Jan — 169S-173S
ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.
Drug safety 1996 Jul;15;72-8 — 1996 Jul — 72-8
Safety profiles of the angiotensin-converting enzyme inhibitors.
Drugs 1988;35 Suppl 5;89-97 — 1988 — 89-97
Post-marketing surveillance of enalapril: experience in 11,710 hypertensive patients in general practice.
The Journal of the Royal College of General Practitioners 1987 Aug;37;346-9 — 1987 Aug — 346-9
The positive association of cough with angiotensin-converting enzyme inhibitors.
Pharmacotherapy 1989;9;82-7 — 1989 — 82-7
[Intractable cough from enalapril].
Anales de medicina interna (Madrid, Spain : 1984) 1991 Dec;8;628 — 1991 Dec — 628