The Drug-Induced Respiratory Disease Website

Methadone

Takotsubo (stress) cardiomyopathy

Cases have also been described following drug overdose (PMID 25172356) or withdrawal (24170890)

Alinejad S, Kazemi T, Zamani N, Hoffman RS, Mehrpour O

A systematic review of the cardiotoxicity of methadone.

EXCLI journal 2015;14;577-600 — 2015 — 577-600

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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