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The Drug-Induced Respiratory Disease Website

Exacerbation ob underlying IPF, was deemed unrelated to the drug in the paper by Ikeda et al., because rechallenge with the drug did not lead to relapse of the exacerbation in the patient

The evidence for nintedanib induced ILD is low-to-very low

Publications

Yonezawa T, Nishizaki S, Kako H, Amano H, Murao H, Fukami M, Ogisu T, Katano T, Ito S

[A CASE OF IDIOPATHIC PULMONARY FIBROSIS WITH SUSPECTED DRUG-INDUCED LUNG INJURY FOLLOWING ACUTE EXACERBATION AFTER NINTEDANIB ADMINISTRATION].

Arerugi = [Allergy] 2025;74;83-88 — 2025 — 83-88

Ikeda S, Sekine A, Baba T, Yamakawa H, Morita M, Kitamura H, Ogura T

Administration of nintedanib after discontinuation for acute exacerbation of idiopathic pulmonary fibrosis: a case report.

BMC pulmonary medicine 2016 Mar 03;16;38 — 2016 Mar 03 — 38