The Drug-Induced Respiratory Disease Website

Benzonatate

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Arrhythmias-Dysrhythmias, including atrial fibrillation (Review at PMID 15582307), ventricular tachycardia/fibrillation See also under torsades de pointe under XIIt

Publications

Yoshioka I, Surmaitis R, Katz KD

A 17-Year-Old Girl With Cough--Pulseless After Drug Overdose. Sodium benzonatate overdose.

Pediatric emergency care 2016 Mar;32;197-9 — 2016 Mar — 197-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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