The Drug-Induced Respiratory Disease Website

Nivolumab

‘Cardiotoxicity’

Including heart failure, cardiomyopathy, heart block, myocarditis, myocardial fibrosis and pericarditis.

Heinzerling L, Ott PA, Hodi FS, Husain AN, Tajmir-Riahi A, Tawbi H, Pauschinger M, Gajewski TF, Lipson EJ, Luke JJ

Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy.

Journal for immunotherapy of cancer 2016;4;50 — 2016 — 50

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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