The Drug-Induced Respiratory Disease Website

Cryobiopsy (transbronchial pulmonary - TBLB-TBLCB)

Major/massive hemoptysis

Can be fatal from blood loss, or clotting in the central airway causing acute airway compromise and respiratory failure

Hackner K, Stadler A, Schragel F, Klamminger V, Ghanim B, Varga A, Errhalt P

Transbronchial lung cryobiopsy: prospective safety evaluation and 90-day mortality after a standardized examination protocol.

Therapeutic advances in respiratory disease 2022 Jan-Dec;16;17534666221077562 — 2022 Jan-Dec — 17534666221077562

DiBardino DM, Haas AR, Lanfranco AR, Litzky LA, Sterman D, Bessich JL

High Complication Rate after Introduction of Transbronchial Cryobiopsy into Clinical Practice at an Academic Medical Center.

Annals of the American Thoracic Society 2017 Jun;14;851-857 — 2017 Jun — 851-857

Johannson KA, Marcoux VS, Ronksley PE, Ryerson CJ

Diagnostic Yield and Complications of Transbronchial Lung Cryobiopsy for Interstitial Lung Disease. A Systematic Review and Metaanalysis.

Annals of the American Thoracic Society 2016 10;13;1828-1838 — 2016 10 — 1828-1838

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.