The Drug-Induced Respiratory Disease Website

Excipients, erroneously/deliberately administered i.v.

Foreign body pulmonary vasculopathy (Excipient lung disease)

See also under Vv. Angiocentric foreign body granulomas may engulf talc, cellulose, starch, silica or crospovidone particles. For acrylate cement, see under under VIh. Review at PMID 23864061

Publications

Hossein-Zadeh Z, Shuman MJ, Rapkiewicz A

Fatal Excipients: An Autopsy Case Series of Excipient Lung Disease.

The American journal of forensic medicine and pathology 2022 Mar 01;43;81-89 — 2022 Mar 01 — 81-89

Cook CM, Simpson SQ, Satterwhite L

Excipient-Induced Pulmonary Vascular Disease: An Underrecognized and Deadly Complication of Opioid Addiction.

Lung 2021 08;199;363-368 — 2021 08 — 363-368

Henry TS, Naeger DM, Looney MR, Elicker BM

Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules.

Annals of the American Thoracic Society 2016 Oct;13;1858-1860 — 2016 Oct — 1858-1860

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

LATEST CHANGELOG

No activity has been recorded yet.

View full changelog