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Capecitabine

Coronary vasospasm - Vasospastic angina

Classically in the form of acute ST changes on EKG, acute coronary event or MI (See under XIIg). After episode, coronary bed/angiogram return to the patent state. May happen without preexisting/underlying CAD

Publications

Kolos IP, Chernyshova VA, Konstantinova EV, Gilyarov MY

[Capecitabine and vasospastic angina: a clinical case].

Kardiologiia 2022 Feb 28;62;36-41 — 2022 Feb 28 — 36-41

Nykamp MJ, Marks L, Kerby PW, Cristancho P

Negative Pressure Pulmonary Edema After Electroconvulsive Therapy.

The journal of ECT 2021 Sep 13;; — 2021 Sep 13

Henry D, Rudzik F, Butts A, Mathew A

Capecitabine-Induced Coronary Vasospasm.

Case reports in oncology 2016 Sep-Dec;9;629-632 — 2016 Sep-Dec — 629-632

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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