The Drug-Induced Respiratory Disease Website

Clopidogrel

Esophageal hematoma (may cause chest pain and/or tracheal compression)

Lee SP, Lee HL, Lee KN

Chest pain in a patient with coronary artery disease taking clopidogrel.

Gastroenterology 2013 Jan;144;e13-4 — 2013 Jan — e13-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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