The Drug-Induced Respiratory Disease Website

Sevoflurane

Alveolar hemorrhage (AH), diffuse AH (DAH)

Likelihood and causality is disputed (PMID 25343207)

Jordan JH, Pedroza S, Billefals ES, Cruz G

Diffuse alveolar hemorrhage induced by inhaled Sevoflurane. Case report and literature review.

Respiratory medicine case reports 2023;45;101906 — 2023 — 101906

Ahmed-Khan M, Moin K, Funk C, Sachdev M, Jiffry MZM

Sevoflurane-Induced Diffuse Alveolar Hemorrhage.

Archive of clinical cases 2023;10;29-31 — 2023 — 29-31

Yasli SO, Dogruel F, Demirbas AE, Canpolat DG

A case of diffuse alveolar hemorrhage after orthognathic surgery: Case report with the literature review'.

Nigerian journal of clinical practice 2022 Jun;25;967-970 — 2022 Jun — 967-970

Mendonça MC, Abreu JB, Gama K

Diffuse Alveolar Hemorrhage After Orotracheal Extubation Probably Induced by Sevoflurane Inhalation.

Archivos de bronconeumologia 2021 Jan 28;; — 2021 Jan 28

Murray AW, Smith JD, Ibinson JW

Diffuse alveolar hemorrhage, anesthesia, and cannabis.

Annals of the American Thoracic Society 2014 Oct;11;1338-9 — 2014 Oct — 1338-9

Kim CA, Liu R, Hsia DW

Diffuse alveolar hemorrhage induced by sevoflurane.

Annals of the American Thoracic Society 2014 Jun;11;853-5 — 2014 Jun — 853-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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