The Drug-Induced Respiratory Disease Website

Osimertinib

Heart failure (biventricular, congestive)

Can occur as a consequence of several pulmonary obliterative vasculopathies. Cardiac tamponade may mimic this condition. See under VI

Fukuo A, Imamura T, Onoda H, Kinugawa K

Successful Management of Osimertinib-Induced Heart Failure.

Medicina (Kaunas, Lithuania) 2022 Feb 18;58; — 2022 Feb 18

Ikebe S, Amiya R, Minami S, Ihara S, Higuchi Y, Komuta K

Osimertinib-induced cardiac failure with QT prolongation and torsade de pointes in a patient with advanced pulmonary adenocarcinoma.

International cancer conference journal 2021 Jan;10;68-71 — 2021 Jan — 68-71

Watanabe H, Ichihara E, Kano H, Ninomiya K, Tanimoto M, Kiura K

Congestive Heart Failure During Osimertinib Treatment for Epidermal Growth Factor Receptor (EGFR)-mutant Non-small Cell Lung Cancer (NSCLC).

Internal medicine (Tokyo, Japan) 2017 Aug 15;56;2195-2197 — 2017 Aug 15 — 2195-2197

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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