The Drug-Induced Respiratory Disease Website

Ticagrelor

Disordered breathing pattern - Cheynes-Stokes respiration

Generally occurring during sleep. See also under IXb, IXu, IXq

Lamberts V, Baele P, Kahn D, Liistro G

Dyspnea or Cheyne-Stokes respiration associated with Ticagrelor?

Sleep medicine 2018 Mar;43;4-6 — 2018 Mar — 4-6

Conte L, Pugliese NR, Giannoni A

Reversal of Ticagrelor-Induced Arrhythmias and Cheyne-Stokes Respiration With Aminophylline Infusion.

Journal of cardiovascular pharmacology 2017 Nov;70;290-292 — 2017 Nov — 290-292

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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