The Drug-Induced Respiratory Disease Website

Abiraterone

Fluid retention

May manifest with weight gain, tissue edema, cardiomegaly and electrlyte disturbances. See also under Xc

Procopio G, Grassi P, Testa I, Verzoni E, Torri V, Salvioni R, Valdagni R, de Braud F

Safety of Abiraterone Acetate in Castration-resistant Prostate Cancer Patients With Concomitant Cardiovascular Risk Factors.

American journal of clinical oncology 2015 Oct;38;479-82 — 2015 Oct — 479-82

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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