The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
Late-onset severe pneumonitis under osimertinib.
AME case reports 2019;3;39 — 2019 — 39
Tachi H, Shiozawa T, Sakai C, Kasuga M, Nakazawa K, Morishima Y, Satoh H, Hizawa N, Sakashita S, Sekine I
Osimertinib-Induced Interstitial Lung Disease Presenting as Eosinophilic Pneumonia.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2017 08;12;e118-e120 — 2017 08 — e118-e120