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The Drug-Induced Respiratory Disease Website

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

IV.a

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

Publications

Gürdo?an M, Yalta K, Gürlertop Y, Karahan F, Bulburu ?B, Koçyi?it B, Ustaba??o?lu FE, Çiçin ?

Coexistence of Anti-PD1-Induced Immune Myocarditis and Complete Atrioventricular Block: A Case Report.

The American journal of cardiology 2023 Sep 16;207;35-38 — 2023 Sep 16 — 35-38

Bukamur HS, Mezughi H, Karem E, Shahoub I, Shweihat Y

Nivolumab-induced Third Degree Atrioventricular Block in a Patient with Stage IV Squamous Cell Lung Carcinoma.

Cureus 2019 Jun 10;11;e4869 — 2019 Jun 10 — e4869

Mir H, Alhussein M, Alrashidi S, Alzayer H, Alshatti A, Valettas N, Mukherjee SD, Nair V, Leong DP

Cardiac Complications Associated With Checkpoint Inhibition: A Systematic Review of the Literature in an Important Emerging Area.

The Canadian journal of cardiology 2018 08;34;1059-1068 — 2018 08 — 1059-1068

Mahmood SS, Fradley MG, Cohen JV, Nohria A, Reynolds KL, Heinzerling LM, Sullivan RJ, Damrongwatanasuk R, Chen CL, Gupta D, Kirchberger MC, Awadalla M, Hassan MZO, Moslehi JJ, Shah SP, Ganatra S, Thavendiranathan P, Lawrence DP, Groarke JD, Neilan TG

Myocarditis in Patients Treated With Immune Checkpoint Inhibitors.

Journal of the American College of Cardiology 2018 Apr 24;71;1755-1764 — 2018 Apr 24 — 1755-1764

Reddy N, Moudgil R, Lopez-Mattei JC, Karimzad K, Mouhayar EN, Somaiah N, Conley AP, Patel S, Giza DE, Iliescu C

Progressive and Reversible Conduction Disease With Checkpoint Inhibitors.

The Canadian journal of cardiology 2017 10;33;1335.e13-1335.e15 — 2017 10 — 1335.e13-1335.e15

Diagnosing DIRD