The Drug-Induced Respiratory Disease Website

Bentazone

Rigid chest syndrome - Chest wall rigidity - Stiff/wooden chest

Stiff chest from chest wall/respiratory muscle spasm. May cause apnea, acute respiratory compromise and death. May associate with tetany/laryngospasm (see also VIIIe and IXi)

Publications

Lee K

A fatal case of acute bentazone overdose despite cricothyroidotomy during cardiopulmonary resuscitation.

Clinical and experimental emergency medicine 2017 Dec;4;254-257 — 2017 Dec — 254-257

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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