The Drug-Induced Respiratory Disease Website

Trastuzumab

Antisynthetase antibodies (ASA) - ASA syndrome

Including flare of preexisting ASA syndrome

Reynolds TD, Mohan V, Roy M, Manghat N, Adamali H, Gunawardena H

An unusual flare of anti-synthetase syndrome during concurrent trastuzumab therapy given for recurrent breast cancer.

European journal of rheumatology 2017 Dec;4;278-280 — 2017 Dec — 278-280

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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