The Drug-Induced Respiratory Disease Website

Denosumab

Hypocalcemia (may lead to respiratory muscle weakness and RF)

De Muynck B, Leys M, Cuypers J, Vanderschueren D, Delcroix M, Belge C

Hypocalcemia after Denosumab in a Pulmonary Hypertension Patient Receiving Epoprostenol.

Respiration; international review of thoracic diseases 2018;95;139-142 — 2018 — 139-142

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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