The Drug-Induced Respiratory Disease Website

Amiodarone

Eye-catcher: An electron-dense ('white') thyroid

Felix L, Jacon P, Lugosi M, Cristante J, Roux J, Chabre O

Rise and fall of thyroid radiologic density during the time course of amiodarone-induced thyrotoxicosis.

European thyroid journal 2022 01 01;11; — 2022 01 01

Van den Bruel A, Delanote J, Braeckman A, De Vroe C, Pyfferoen L, Ghekiere J, Duytschaever M, Tavernier R

"White Thyroid" on Unenhanced Computed Tomography in Amiodarone-Induced Thyrotoxicosis Type 2.

Thyroid : official journal of the American Thyroid Association 2018 06;28;769-772 — 2018 06 — 769-772

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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