The Drug-Induced Respiratory Disease Website

Apatinib

Major/massive hemoptysis

Can be fatal from blood loss, or clotting in the central airway causing acute airway compromise and respiratory failure

Wang W, Zhang L, Xie Y, Zhen T, Su G, Zang Q

Fatal hemoptysis in patients with advanced esophageal cancer treated with apatinib.

OncoTargets and therapy 2018;11;2565-2570 — 2018 — 2565-2570

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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