The Drug-Induced Respiratory Disease Website

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

Shrinking lung syndrome

May be difficult to separate from IXa. See also under Xd

Nishino M, Hatabu H, Sholl LM, Ramaiya NH

Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care.

Radiographics : a review publication of the Radiological Society of North America, Inc 2017 Sep-Oct;37;1371-1387 — 2017 Sep-Oct — 1371-1387

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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