The Drug-Induced Respiratory Disease Website

Liposuction

Path: Lipid/fat embolism

Specific staining may be required to separate exogenous/foreign lipids from fat and silicone (PMID 23020716)

Cantu CA, Pavlisko EN

Liposuction-Induced Fat Embolism Syndrome: A Brief Review and Postmortem Diagnostic Approach.

Archives of pathology & laboratory medicine 2018 07;142;871-875 — 2018 07 — 871-875

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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