The Drug-Induced Respiratory Disease Website

Hydroxychloroquine

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

Chatre C, Roubille F, Vernhet H, Jorgensen C, Pers YM

Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature.

Drug safety 2018 10;41;919-931 — 2018 10 — 919-931

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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