The Drug-Induced Respiratory Disease Website

Abiraterone

Pulmonary edema, cardiogenic

(Fr: OAP cardiogénique). Can result from left or biventricular dysfunction/failure. See also under XIIa, XIId, XIIai

Tsugu T, Nagatomo Y, Nakajima Y, Kageyama T, Akise Y, Endo J, Itabashi Y, Murata M, Mitamura H

Cancer therapeutics-related cardiac dysfunction in a patient treated with abiraterone for castration-resistant prostate cancer.

Journal of medical ultrasonics (2001) 2019 Apr;46;239-243 — 2019 Apr — 239-243

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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