The Drug-Induced Respiratory Disease Website

Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC

Coagulopathy

May stem from thrombocytopenia or pancytopenia, DIC, drug-drug interaction with an vitamin K antagonist, or direct vitamin K antagonism. May lead to any pattern of bleeding under pattern family II

Publications

Samuelson BT, Cuker A, Siegal DM, Crowther M, Garcia DA

Laboratory Assessment of the Anticoagulant Activity of Direct Oral Anticoagulants: A Systematic Review.

Chest 2017 Jan;151;127-138 — 2017 Jan — 127-138

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

LATEST CHANGELOG

No activity has been recorded yet.

View full changelog