The Drug-Induced Respiratory Disease Website

Trastuzumab

Guillain-Barré (or GB-like) syndrome (w/wo ARF)

ARF: acute resiratory failure

Bettini AC, Tondini C, Poletti P, Caremoli ER, Guerra U, Labianca R

A case of interstitial pneumonitis associated with Guillain-Barré syndrome during administration of adjuvant trastuzumab.

Tumori 2008 Sep-Oct;94;737-41 — 2008 Sep-Oct — 737-41

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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