The Drug-Induced Respiratory Disease Website

Eosinophilic myocarditis

Yamamoto H, Hashimoto T, Ohta-Ogo K, Ishibashi-Ueda H, Imanaka-Yoshida K, Hiroe M, Yokochi T

A case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2018 Nov - Dec;37;54-57 — 2018 Nov - Dec — 54-57

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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