The Drug-Induced Respiratory Disease Website

Pembrolizumab

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

Khan A, Riaz S, Carhart R

Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block.

Case reports in cardiology 2020;2020;8428210 — 2020 — 8428210

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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