The Drug-Induced Respiratory Disease Website

Lamotrigine

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

French LK, McKeown NJ, Hendrickson RG

Complete heart block and death following lamotrigine overdose.

Clinical toxicology (Philadelphia, Pa.) 2011 Apr;49;330-3 — 2011 Apr — 330-3

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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