The Drug-Induced Respiratory Disease Website

Beta-blockers

Exacerbation or deterioration of preexisting asthma

Fallowfield JM, Marlow HF

Propranolol is contraindicated in asthma.

BMJ (Clinical research ed.) 1996 Dec 07;313;1486 — 1996 Dec 07 — 1486

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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