The Drug-Induced Respiratory Disease Website

Pregabalin

Disordered breathing during sleep - Sleep apnea

Including prolongation of apnea. PMID 27735059, 33965721.

Revol B, Jullian-Desayes I, Cracowski JL, Tamisier R, Mallaret M, Joyeux-Faure M, Pepin JL

Gabapentinoids and sleep apnea syndrome: a safety signal from the WHO pharmacovigilance database.

Sleep 2019 Feb 01;42; — 2019 Feb 01

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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