The Drug-Induced Respiratory Disease Website

Cabozantinib

Major/massive hemoptysis

Can be fatal from blood loss, or clotting in the central airway causing acute airway compromise and respiratory failure

Hellerstedt BA, Vogelzang NJ, Kluger HM, Yasenchak CA, Aftab DT, Ramies DA, Gordon MS, Lara P

Results of a Phase II Placebo-controlled Randomized Discontinuation Trial of Cabozantinib in Patients with Non-small-cell Lung Carcinoma.

Clinical lung cancer 2019 03;20;74-81.e1 — 2019 03 — 74-81.e1

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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