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The Drug-Induced Respiratory Disease Website

See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812

Publications

Oh S, Cha SI, Kim H, Kim M, Choi SH, Seo H, Park TI

A case of venlafaxine-induced interstitial lung disease.

Tuberculosis and respiratory diseases 2014 Aug;77;81-4 — 2014 Aug — 81-4

Tsigkaropoulou E, Hatzilia D, Rizos E, Christodoulou C, Loukides S, Papiris S, Lykouras L

Venlafaxine-induced acute eosinophilic pneumonia.

General hospital psychiatry 2011 Jul-Aug;33;411.e7-9 — 2011 Jul-Aug — 411.e7-9

Oermann CM, Panesar KS, Langston C, Larsen GL, Menendez AA, Schofield DE, Cosio C, Fan LL

Pulmonary infiltrates with eosinophilia syndromes in children.

The Journal of pediatrics 2000 Mar;136;351-8 — 2000 Mar — 351-8

Fleisch MC, Blauer F, Gubler JG, Kuhn M, Scherer TA

Eosinophilic pneumonia and respiratory failure associated with venlafaxine treatment.

The European respiratory journal 2000 Jan;15;205-8 — 2000 Jan — 205-8